In this paper, the setup of the mobile robot was first described. By imitating the preview driving behavior of human, an effective intelligent preview control method for mobile robot road following was developed. The operating principle, construction and the design process of the controller were also described. The test results show that the mobile robot controlled by the proposed approach can follow various reference paths accurately and robustly. A complete mobile robot control system with the function of obstacle avoidance will be developed in the subsequent research.