Abstract: The underwater vehicle manipulation simulation calculation is studied with the CFD(computational fluid dynamics) simulation softwares of CFX and USAERO,and the simulation calculation data is compared with the experimental data on a model.Feasibility of the simulation calculation is validated and the applied range of simulation calculation is pointed out.Some manipulation experiments that can’t be done practically can be finished through simulation calculation,and it has practical significance for reducing the cost of model experiments and studying the underwater vehicle’s manipulation,especially for manipulation design in the scheme design phase.