Abstract: This paper presents a method to implement interactive nanomanipulation.With the method we develop an interactive nanomanipulation system with force feedback and visual feedback.Using the system the operator can not only feel the real-time forces acting on the probe of atomic force microscope(AFM) but also observe the real-time changes of nano-environment under the operation of AFM probe.It makes the operation in micro-world intuitive and flexible as moving object in macro-world.The experimental results prove the efficiency and advantages of the system.