Abstract: A telecontrol navigation system for bio-robot is developed, which is applicable to the navigation control of rats by stimulating some particular brain areas. The system basically consists of two parts, i.e., wireless parameters transmitter device (WPTD) and implantable neural stimulation system (INSS). The WPTD contains a single-chip microcomputer (C8051F330), a wireless frequency modulation (FM) transmitter chip (QN8027) and power amplifier (PA) circuits. The INSS includes a C8051F330, a wireless FM receiver chip (QN8025), analog switches, and implantable electrodes. The INSS is fabricated of surface mount devices (SMD) with the dimension of 20mm? 15mm?3mm, weight of 6g (including a rechargeable lithium battery, 3g). Lateral medial forebrain bundle (MFB) and ventral posterlateral thalamic nucleus (VPL) are selected as the brain sites to be stimulated, and each brain site is implanted into a pair of electrodes. Each pair of electrodes as one channel is connected with INSS, so that WPTD can regulate the signal parameters of the neural stimulation in each channel in real time. Experiments indicate that the current stimulation of MFB with proper parameters can drives the rat to move forward as virtual reward, while the current stimulation of VPL with proper parameters can cause the rat to turn left or right.